期刊论文详细信息
Marine Drugs
Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity
Shogo Mori1  Coran M. H. Watanabe1  Howard Williams1  Kristopher Karanovich2  F. David Horgen2  Davey Cagle2  Roger Smith III3 
[1] Department of Chemistry, Texas A&M University, College Station, TX 77843, USA;Department of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USA;Department of Veterinary Pathology, Texas A&M University, College Station, TX 77843, USA;
关键词: macrolactone;    polyketide;    cyanobacteria;    chemotaxis;    cell cycle;   
DOI  :  10.3390/md13106274
来源: DOAJ
【 摘 要 】

A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.

【 授权许可】

Unknown   

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