Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity

Marine Drugs

Shogo Mori¹  Coran M. H. Watanabe¹  Howard Williams¹  Kristopher Karanovich²  F. David Horgen²  Davey Cagle²  Roger Smith III³ 

[1] Department of Chemistry, Texas A&M University, College Station, TX 77843, USA;Department of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USA;Department of Veterinary Pathology, Texas A&M University, College Station, TX 77843, USA;

关键词: macrolactone;    polyketide;    cyanobacteria;    chemotaxis;    cell cycle;   

DOI  :  10.3390/md13106274

来源: DOAJ

【 摘 要 】

A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.

【 授权许可】

Unknown