Synthesis of the C1-C9 fragment of the potent antitumor agent dictyostatin

Journal of the Brazilian Chemical Society

Luiz C. Dias¹  Danilo P. Sant'ana¹  Ygor W. Vieira¹  Caroline C. S. Gonçalves¹  Dimas J. P. Lima¹ 

[1] ,Universidade Estadual de Campinas Instituto de Química Campinas SP ,Brazil

关键词: total synthesis;    dictyostatin;    Sharpless asymmetric epoxidation;    macrolactone;   

DOI  :  10.1590/S0103-50532012000200022

来源: SciELO

【 摘 要 】

We describe herein a short and efficient synthesis of the C1-C9 fragment of the potent antitumor agent dictyostatin. Notable features of this approach include a Sharpless asymmetric epoxidation followed by epoxide opening under Myashita's conditions to introduce the stereogenic centers at C6 and C7, and a Horner-Wadsworth-Emmons type reaction under Ando's conditions to construct the Z-double bond of the 1,3-(Z,E)-diene system.

【 授权许可】

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