Synthesis of the C1-C9 fragment of the potent antitumor agent dictyostatin

Journal of the Brazilian Chemical Society

Sant'Ana, Danilo P.¹  Gonçalves, Caroline C. S.¹  Vieira, Ygor W.¹  Universidade Estadual de Campinas, Campinas, Brazil¹  Lima, Dimas J. P.¹  Dias, Luiz C.¹ 

关键词: total synthesis;    dictyostatin;    Sharpless asymmetric epoxidation;    macrolactone;   

DOI  :  10.1590/S0103-50532012000200022

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

We describe herein a short and efficient synthesis of the C1-C9 fragment of the potent antitumor agent dictyostatin. Notable features of this approach include a Sharpless asymmetric epoxidation followed by epoxide opening under Myashita's conditions to introduce the stereogenic centers at C6 and C7, and a Horner-Wadsworth-Emmons type reaction under Ando's conditions to construct the Z-double bond of the 1,3-(Z,E)-diene system.

【 授权许可】

Unknown