Stereoselective Synthesis of D-5’-Homo-4’-selenonucleosides as Potent Therapeutic Agents

D-5’-Homo-4’-selenonucleosides;Sharpless asymmetric epoxidation;Regioselective cleavage;Stereoselective reduction;615

약학대학 약학과 ;

University:서울대학교 대학원

关键词: D-5’-Homo-4’-selenonucleosides;    Sharpless asymmetric epoxidation;    Regioselective cleavage;    Stereoselective reduction;    615;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/133627/1/000000133435.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

D-5’-Homo-4’-selenonucleosides were synthesized from D-5-homo-4-selenoribose using a Pummerer-type condensation. For the stereoselective synthesis of the key intermediate D-5-homo-4-selenoribose, we employed Sharpless asymmetric epoxidation, regioselective epoxide cleavage, and stereoselective reduction of the ketone as the key steps.