Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity

Marine Drugs

Shogo Mori²  Howard Williams²  Davey Cagle³  Kristopher Karanovich³  F. David Horgen³  Roger Smith¹  Coran M. H. Watanabe² 

[1] Department of Veterinary Pathology, Texas A&M University, College Station, TX 77843, USA; E-Mail:;Department of Chemistry, Texas A&M University, College Station, TX 77843, USA; E-Mails:;Department of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USA; E-Mails:

关键词: macrolactone;    polyketide;    cyanobacteria;    chemotaxis;    cell cycle;   

DOI  :  10.3390/md13106274

来源: mdpi

【 摘 要 】

A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.