Study on the relationship between hepatic fibrosis and epithelial-mesenchymal transition in intrahepatic cells

Biomedicine & Pharmacotherapy

Jing-tao Li¹  Bing Xu²  Dong-yan Guo³  Xiao-yan Shi⁴  Yu Fan⁵  Yang Chen⁵  Li-fang Duan⁶ 

[1] Corresponding author at: Shaanxi Key Laboratory of New Drugs and Chinese Medicine Foundation Research, College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-Xianyang New Ecomic Zone, Xianyang, Shaanxi, 712046, China.;Corresponding author at: The Basic Medical College, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-Xianyang New Ecomic Zone, Xianyang, Shaanxi, 712046, China.;Shaanxi Province Key Laboratory of Basic and New Herbal Medicament Research, Xianyang 712046, China;Shaanxi Province Key Laboratory of Basic and New Herbal Medicament Research, Xianyang 712046, China;The Basic Medical College of Shaanxi University of Chinese Medicine, Xianyang 712046, China;The Medical Technical College of Shaanxi University of Chinese Medicine, Xianyang 712046, China;

关键词: Hepatic fibrosis;    Epithelial-mesenchymal transition;    Hepatocytes;    Hepatic stellate cells;    Bile duct cells;    Mechanism research;   

DOI  :  

来源: DOAJ

【 摘 要 】

Hepatic fibrosis is a pathophysiological process, which causes excessive extracellular matrix (ECM) deposition resulting from persistent liver damage. Myofibroblasts are the core cells that produce ECM. It is known that epithelial-mesenchymal transition (EMT) is not a simple transition of cells from the epithelial to mesenchymal state. Instead, it is a process, in which epithelial cells temporarily lose cell polarity, transform into interstitial cell-like morphology, and acquire migration ability. Hepatocytes, hepatic stellate cells, and bile duct cells are the types of intrahepatic cells found in the liver. They can be transformed into myofibroblasts via EMT and play important roles in the development of hepatic fibrosis through a maze of regulations involving various pathways. The aim of the present study is to explore the relationship between the relevant regulatory factors and the EMT signaling pathways in the various intrahepatic cells.

【 授权许可】

Unknown