Study on the structures and anti-hepatic fibrosis activity of stilbenoids from Arundina graminifolia (D. Don) Hochr.

1st International Conference on Frontiers of Materials Synthesis and Processing

材料科学;化学

Liu, Qingqing^1 ; Wang, Huiting^1 ; Lin, Fankai^1 ; Dai, Rongji^1 ; Yu, Deng Lin^1 ; Lv, Fang^1

School of Life Science, Beijing Key Laboratory for Separation, Analysis in Biomedicine and Pharmaceuticals, Beijing Institute of Technology, Beijing

100081, China^1

关键词: Hepatic fibrosis;    In-vitro;    Inhibitory effect;    Isolated compounds;    Ms spectrum;    Phytochemical;    Semi-preparative HPLC;    Stilbenoids;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/274/1/012024/pdf
DOI  :  10.1088/1757-899X/274/1/012024

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

A phytochemical study was performed on Arundina graminifolia (D.Don) Hochr. by silica gel column and semi-preparative HPLC, and ten stilbenoids were obtained. Their structures were elucidated by NMR and MS spectra and identified as 7-hydroxy-2,4-dimethoxy-9,10-dihydrophenanthrene (1), 4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene (2), 2,7-dihydroxy-4-methoxy-9,10-dihydrophenanthrene (3), 3,3'-dihydroxy-5-methoxy-bibenzyl (4), 7-hydroxy-2,8-dimethoxy-phenanthrene-1,4-dione (5), 7-hydroxy-2,10-dimethoxy-phenanthre-ne-1,4-dione (6), 7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene-1,4-dione (7), 7-hydroxy-2-methoxy-phenanthrene-1,4-dione (8), 7-hydroxy-1-(p-hydroxybenzyl)-2,4-dimethoxy-9,10-dihydroxy-phenanthrene (9), 2,7-dihydroxy-1-(p-hydroxybenzyl)-4-methoxy-9,10-dihydroxy-phenanthrene (10). Compounds 5 and 6 were isolated from this plant for the first time. The isolated compounds were examined for their anti-hepatic fibrosis activity against HSC-T6 cells in vitro. The results showed that compounds 4 and 5 exhibited moderate growth inhibitory effects with IC50 61.9 μg/mL and 52.7 μg/mL, respectively.