RNA methylations in hepatic fibrosis, a gradually emerging new treatment strategy

Cell & Bioscience

Review

Xiao Wang¹  Qiangjun Duan²  Faxue Liao³  Qiuyun Xue⁴  Yajie Wu⁴  Chenglong Cheng⁴  Xin Wang⁴  Yurong Huang⁴  Chenggui Miao⁵ 

[1] Department of Clinical Nursing, School of Nursing, Anhui University of Chinese Medicine, Hefei, China;Department of Experimental (Practical Training) Teaching Center, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China;Department of Orthopaedics, The First Affiliated Hospital, Anhui Medical University, Hefei, China;Anhui Public Health Clinical Center, Hefei, China;Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China;Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China;Institute of Rheumatism, Anhui University of Chinese Medicine, Hefei, China;

关键词: Epigenetics;    Hepatic fibrosis;    RNA methylation;    N6-methyladenosine;    Hepatic stellate cells;   

DOI  :  10.1186/s13578-023-01066-8

 received in 2023-03-04, accepted in 2023-06-06,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundHepatic fibrosis (HF) is a pathological process caused by excessive accumulation of extracellular matrix caused by a series of causes, leading to the formation of fiber scar. RNA methylation is a newly discovered epigenetic modification that exists widely in eukaryotes and prokaryotes and plays a crucial role in the pathogenesis of many diseases.ResultsThe occurrence and development of HF are regulated by many factors, including excessive deposition of extracellular matrix, activation of hepatic stellate cells, inflammation, and oxidative stress. RNA methylations of different species have become a crucial regulatory mode of transcript expression, And participate in the pathogenesis of tumors, nervous system diseases, autoimmune diseases, and other diseases. In addition, there are five common types of RNA methylation, but only m6A plays a crucial regulatory role in HF. The pathophysiological regulation of m6A on HF is achieved by the combination of the methylated transferase, demethylated enzyme, and methylated reading protein.ConclusionsRNA methylated methyltransferase, demethylase, and reading protein extensively affect the pathological mechanism of HF, which may be a new therapeutic and diagnostic target, representing a new class of therapeutic strategies.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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