Effect of Mahkota Dewa Ethanolic Extracts (Phaleria macrocarpa Scheff.) to Hepar Histology of Female Rat (Rattus novergicus) In Preeclampsia

4th International Conference on Biological Sciences and Biotechnology

Ilyas, S.^1 ; Tanjung, M.^1^2 ; Nurwahyuni, I.^1 ; Pasaribu, F.Y.^1

Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia^1

Center of Excellence for Natural Resources-Based Technology, Mangrove and Bio-Resources Group Universitas Sumatera Utara, Medan, Indonesia^2

关键词: Control groups;    Ethanolic extracts;    Hematoxylin eosin;    Hepatocytes;    Histological observations;    Macrocarpa;    Morphological observations;    Preeclampsia;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/305/1/012075/pdf
DOI  :  10.1088/1755-1315/305/1/012075

来源: IOP

【 摘 要 】

Preeclampsia is a disease at 20 weeks' gestation which is characterized by an abnormal increase in blood pressure (Hypertension) and Proteunaria. This study used a type of analytic study with an experimental quasi design in pregnant female rats (Rattus norvegicus) consisting of four treatments with six replications each. The study consisted of a control group (K) which was only fed ad libitum, Treatment 1 (P1) was injected with LPS intervena at a dose of 0.2 / kgBW, and the group was given extract of Mahkota Dewa Plant (Phaleria macrocarpa Scheff.) With each dose -one of 100 mg / kgBW (P2) and 200 mg / kgBW (P3). Rat liver organ (Rattus norvegicus) is taken after surgery. Liver organ is made into a preservative preparation with paraffin method and staining of Hematoxylin-Eosin (HE). Morphological observations showed a marked decrease in liver weight (p0.05).