A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier

Clinical and Molecular Hepatology

Chang Soo Eun¹  Tae Yeob Kim¹  Joong Ho Bae¹  Joo Hyun Sohn¹  Hye Sun Park¹  Dong Soo Han¹  Yil Sik Hyun¹  Yong Cheol Jeon¹  Hye Soon Lee² 

[1] Division of Gastroenterology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.;Division of Rheumatology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.;

关键词: Hepatitis B virus;    Liver failure;    Steroids;    Virus activation;   

DOI  :  10.3350/cmh.2012.18.2.225

来源: DOAJ

【 摘 要 】

Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended. Most reported cases of reactivation are associated with high doses of immunosuppressive agents or combination therapy. We present a case of a previously inactive HBV carrier with an acute severe flare-up during a long-term, very-low-dose (2.5 mg/day) steroid treatment for rheumatoid arthritis. We suggest that even a minimal dose of single-regimen oral steroid can cause reactivation of indolent, inactive HBV.

【 授权许可】

Unknown