Controlled Release of Amoxicillin from Bis(2-hydroxyethyl)amine Functionalized SBA-15 as a Mesoporous Sieve Carrier

Journal of Chemical Health Risks

Mohammad Reza Ganjali¹  Ghodsi Mohammadi Ziarani²  Nafiseh Yaghobi³  Leila Hajiaghababaei⁴  Alireza Badiei⁵ 

[1] Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran;Department of Chemistry, Alzahra University, Tehran, Iran;Department of Chemistry, Yadegar -e- Imam Khomeini (RAH) Shahre Rey Branch, Islamic Azad University, Tehran, Iran;Department of Chemistry, Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran;School of Chemistry, College of Science, University of Tehran, Tehran, Iran;

关键词: Bis (2- hydroxy ethyl) amine functionalized mesoporous SBA-15;    Amoxicillin;    Controlled release;    Drug delivery;   

DOI  :  10.22034/jchr.2019.668191

来源: DOAJ

【 摘 要 】

In this study, Bis (2-hydroxyethyl)amine functionalized mesoporous SBA-15 was synthesized for utilization in amoxicillin drug-delivery. Amoxicillin could absorb on the prepared functionalized SBA-15.  A solution of amoxicillin in a suitable solvent was used for this purpose. Amoxicillin molecules release from the matrix into a simulated body fluid (SBF) solution, and phosphate buffers were studied. UV-Vis spectrophotometric method was chosen for amoxicillin determination. Thermogravimetric analysis (TGA), scanning electron microscopy (SEM), nitrogen adsorption–desorption, and powder X-ray diffraction (XRD) technique were applied for characterization of the synthesized materials. The best loading of amoxicillin was done at pH 8.5 after stirring for 30 minutes. The results showed that, at lower pH, releasing of the drug was done faster than it at higher pH. Also, the average release rate of amoxicillin in the body fluid samples that were simulated was about 7 µg h^-1. A highly slow release pattern was observed. The proposed material can be used for enhancing the medical impact of amoxicillin and carrying amoxicillin.

【 授权许可】

Unknown