Preparation of a novel breviscapine-loaded halloysite nanotubes complex for controlled release of breviscapine

2017 International Conference on Material Engineering and Manufacturing

Gao, Min^1 ; Lu, Liqian^1 ; Wang, Xiaoyue^1 ; Lin, Houke^1 ; Zhou, Qingsong^1

School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang

330013, China^1

关键词: Controlled release;    Fourier transform infra red (FTIR) spectroscopy;    Half lives;    Halloysite nanotube (HNTs);    Halloysite nanotubes;    Release rate;    Sustained release;    Vacuum process;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/265/1/012011/pdf
DOI  :  10.1088/1757-899X/265/1/012011

来源: IOP

【 摘 要 】

For sustain the release rate and prolong half-life of breviscapine in vivo, the breviscapine-loaded halloysite nanotubes complex was prepared. The breviscapine was encapsulated into halloysite nanotubes (HNTs) using a vacuum process. The complex were investigated by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), transmission electron microscope (TEM), X-ray diffraction (XRD) and fourier transform infrared spectroscopy(FT-IR). The formation of breviscapine-loaded HNTs complex was proved by the test results of SEM, DSC, TEM and IR analysise. The results confirmed that breviscapine was successfully loaded in the halloysite nanotubes. Additionally, the in vitro drug release of breviscapine from breviscapine-loaded HNTs complex was investigated, the result indicated this complex has apparent sustained-release effect.