Synthesis and characterization of imidazolium ILs based chitosan_tripolyphosphate microparticles

International Conference on Process Engineering and Advanced Materials 2018

Safdar, Rizwan^1 ; Omar, Abdul Aziz^1 ; Arunagiri, A.^2 ; Thanabalan, Murugesan^1

Chemical Engineering Department, Universiti Teknologi PETRONAS, Bandar Seri Iskandar, Perak Darul Ridzuan

32610, Malaysia^1

Chemical Engineering Department, National Institute of Technology, Tiruchirappalli, Tamil Nadu

620 015, India^2

关键词: Controlled release;    Drug carrier;    Drug release;    Imidazolium-based;    Methylimidazolium hydrogen sulfate;    Micro-particles;    Synthesis and characterizations;    Tripolyphosphates;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/458/1/012080/pdf
DOI  :  10.1088/1757-899X/458/1/012080

来源: IOP

【 摘 要 】

In this work, two imidazolium based ILs, 1-butyl-3- methylimidazolium hydrogen sulfate [bmim][HSO4] and 1-butyl-3- methylimidazolium acetate [bmim][Ac] were blended with Chitosan (CS) to synthesize the CS-IL-TPP microparticles. The prepared microparticles were characterized by Zetasizer, FTIR, TGA, SEM and elemental analysis (EDX). The addition of these ILs resulted in controlled sized microparticles which possessed good thermal stability. The elemental analysis indicated that the better crosslinking of tripolyphosphate (TPP) with CS was achieved in the presence of IL, [bmim] [Ac] as compared with [bmim] [HSO4] and CS-TPP formulation alone. The better crosslinking might result in the formation of stable and compact microparticles which could have a better control over the drug release applications. Therefore, this kind of IL might be suitable for improving the characteristics of chitosan as a drug carrier which could ultimately provide controlled release of unstable drugs.