Metabolites from Marine Sponges and Their Potential to Treat Malarial Protozoan Parasites Infection: A Systematic Review

Marine Drugs

AnnaCaroline Campos Aguiar¹  AnaCláudia Muniz Renno¹  MarcosLeoni Gazarini¹  RenataNeves Granito¹  JuliaRisso Parisi¹  LorenaRamos Freitas de Sousa² 

[1] Department of Biosciences, Federal University of São Paulo (UNIFESP), Rua Silva Jardim 136, Santos 11015-020, SP, Brazil;Special Academic Unit of Chemistry, Federal University of Goiás (UFG/UFCAT), Catalão Regional, Catalão 75704-020, GO, Brazil;

关键词: Plasmodium;    malaria;    sponge;    resistance;    antimalarial;   

DOI  :  10.3390/md19030134

来源: DOAJ

【 摘 要 】

Malaria is an infectious disease caused by protozoan parasites of the Plasmodium genus through the bite of female Anopheles mosquitoes, affecting 228 million people and causing 415 thousand deaths in 2018. Artemisinin-based combination therapies (ACTs) are the most recommended treatment for malaria; however, the emergence of multidrug resistance has unfortunately limited their effects and challenged the field. In this context, the ocean and its rich biodiversity have emerged as a very promising resource of bioactive compounds and secondary metabolites from different marine organisms. This systematic review of the literature focuses on the advances achieved in the search for new antimalarials from marine sponges, which are ancient organisms that developed defense mechanisms in a hostile environment. The principal inclusion criterion for analysis was articles with compounds with IC₅₀ below 10 µM or 10 µg/mL against P. falciparum culture. The secondary metabolites identified include alkaloids, terpenoids, polyketides endoperoxides and glycosphingolipids. The structural features of active compounds selected in this review may be an interesting scaffold to inspire synthetic development of new antimalarials for selectively targeting parasite cell metabolism.

【 授权许可】

Unknown