Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?

Cells

Jhully Azevedo dos Santos Pinheiro¹  Diego Marques¹  Cíntia Braga-da-Silva¹  Giovanna C. Cavalcante¹  Ândrea Ribeiro-dos-Santos¹  Camille Sena-dos-Santos¹ 

[1] Programa de Pós-Graduação em Genética e Biologia Molecular, Laboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66.075-110, Brazil;

关键词: malaria;    Plasmodium;    immune response;    cell death;   

DOI  :  10.3390/cells10020479

来源: DOAJ

【 摘 要 】

Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this disease, continuing to cause major public health and socioeconomic problems, especially in low-income countries. Cell death is implicated in malaria immune responses by eliminating infected cells, but it can also provoke an intense inflammatory response and lead to severe malaria outcomes. The study of the pathophysiological role of cell death in malaria in mammalians is key to understanding the parasite–host interactions and design prophylactic and therapeutic strategies for malaria. In this work, we review malaria-triggered cell death pathways (apoptosis, autophagy, necrosis, pyroptosis, NETosis, and ferroptosis) and we discuss their potential role in the development of new approaches for human malaria therapies.

【 授权许可】

Unknown