Vector-Focused Approaches to Curb Malaria Transmission in the Brazilian Amazon: An Overview of Current and Future Challenges and Strategies

Tropical Medicine and Infectious Disease

Roberto Galizi¹  Frederic Tripet¹  JaymeA. Souza-Neto²  BiancaCechetto Carlos²  Maisada Silva Araujo³  Osvaldo Marinotti⁴  ElersonMatos Rocha⁵  Ricardode Melo Katak⁵  JuanCampos de Oliveira⁵ 

[1] Centre of Applied Entomology and Parasitology, School of Life Sciences, Keele University, Staffordshire ST5 5GB, UK;Department of Bioprocesses and Biotechnology, School of Agricultural Sciences, São Paulo State University (UNESP), 18610-034 Botucatu, Brazil;Laboratory of Medical Entomology, Oswaldo Cruz Foundation, FIOCRUZ RONDONIA, 76812-245 Porto Velho, RO, Brazil;MTEKPrime, Aliso Viejo, CA 92656, USA;Programa de Pós-Graduação em Biotecnologia, Universidade Federal do Amazonas - PPGBIOTEC/UFAM, 69067-005 Manaus, Brazil;

关键词: malaria;    Amazon;    Brazil;    Anopheles darlingi;    Plasmodium;    control;   

DOI  :  10.3390/tropicalmed5040161

来源: DOAJ

【 摘 要 】

In Brazil, malaria transmission is mostly confined to the Amazon, where substantial progress has been made towards disease control in the past decade. Vector control has been historically considered a fundamental part of the main malaria control programs implemented in Brazil. However, the conventional vector-control tools have been insufficient to control or eliminate local vector populations due to the complexity of the Amazonian rainforest environment and ecological features of malaria vector species in the Amazon, especially Anopheles darlingi. Malaria elimination in Brazil and worldwide eradication will require a combination of conventional and new approaches that takes into account the regional specificities of vector populations and malaria transmission dynamics. Here we present an overview on both conventional and novel promising vector-focused tools to curb malaria transmission in the Brazilian Amazon. If well designed and employed, vector-based approaches may improve the implementation of malaria-control programs, particularly in remote or difficult-to-access areas and in regions where existing interventions have been unable to eliminate disease transmission. However, much effort still has to be put into research expanding the knowledge of neotropical malaria vectors to set the steppingstones for the optimization of conventional and development of innovative vector-control tools.

【 授权许可】

Unknown