Comparison of Antioxidant and Anticancer Properties of Soft Coral-Derived Sinularin and Dihydrosinularin

Molecules

Li-Ching Lin¹  Ruei-Nian Li²  Hsueh-Wei Chang²  Sheng-Chieh Wang²  Jyh-Horng Sheu³  Jui-Hsin Su⁴  Jen-Yang Tang⁵ 

[1] Chi-Mei Foundation Medical Center, Department of Radiation Oncology, Tainan 71004, Taiwan;Department of Biomedical Science and Environmental Biology, Ph.D. Program in Life Sciences, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan;National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan;School of Post-Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;

关键词: antioxidant;    cytotoxicity;    soft coral;    marine natural products;    sinularin;    dihydrosinularin;   

DOI  :  10.3390/molecules26133853

来源: DOAJ

【 摘 要 】

Marine natural products are abundant resources for antioxidants, but the antioxidant property of the soft corals-derived sinularin and dihydrosinularin were unknown. This study aimed to assess antioxidant potential and antiproliferation effects of above compounds on cancer cells, and to investigate the possible relationships between them. Results show that sinularin and dihydrosinularin promptly reacted with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), and hydroxyl (^•OH), demonstrating a general radical scavenger activity. Sinularin and dihydrosinularin also show an induction for Fe⁺³-reduction and Fe⁺²-chelating capacity which both strengthen their antioxidant activities. Importantly, sinularin shows higher antioxidant properties than dihydrosinularin. Moreover, 24 h ATP assays show that sinularin leads to higher antiproliferation of breast, lung, and liver cancer cells than dihydrosinularin. Therefore, the differential antioxidant properties of sinularin and dihydrosinularin may contribute to their differential anti-proliferation of different cancer cells.

【 授权许可】

Unknown