Cytotoxic Cembranes from Indonesian Specimens of the Soft Coral Nephthea sp.

Marine Drugs

Hedi Indra Januar¹  Ekowati Chasanah¹  Cherie A. Motti²  Dianne M. Tapiolas²  Catherine H. Liptrot² 

[1] Indonesia Research Center for Marine and Fisheries Product Processing and Biotechnology, Jl. KS Tubun Petamburan VI, Jakarta 10260, Indonesia; E-Mails:;Australian Institute of Marine Science, PMB No. 3, Townsville MC, Townsville, 4810, Australia; E-Mails:

关键词: Indonesia;    marine natural products;    soft coral;    Nephthea sp.;    anticancer;    NMR;    cembrane;   

DOI  :  10.3390/md8072142

来源: mdpi

【 摘 要 】

Methanol extracts of two specimens of the soft coral Nephthea sp. collected from the Seribu Islands, Indonesia, were active in an anticancer bioassay. One new (1) and four known diterpenes (2–5) based on the cembrane carbon skeleton were isolated from these extracts, as was arachidonic acid (8). The structures of all compounds were elucidated using NMR, including 1,1-ADEQUATE and 1D gradient selective NOESY where applicable to determine the relative stereochemistry. Spectroscopic data, including ¹H and ¹³C NMR, UV, IR and optical rotations are reported when enough material was available and where this has not been done previously. Inhibition assays employing three cancer cell lines; SF-268 (CNS), MCF-7 (breast), and H460 (lung) were used to guide the isolation of all compounds.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland