Nuclear Magnetic Resonance Project at the Medical University of South Carolina

Lacy, Eric R.

关键词: nuclear magnetic resonance;    marine natural products;   

DOI  :  10.2172/927520
RP-ID  :  doe/er/63385-1Final Report
PID  :  OSTI ID: 927520

美国|英语

来源: SciTech Connect

【 摘 要 】

Department of Energy funds were used to support the development of a Center for Marine Structural Biology at the Marine Resources Center at Ft. Johnson in Charleston, South Carolina. The Ft. Johnson site is home to five institutions in a unique state/federal/academic partnership whose member institutions include the National Ocean Service (NOS), the National Institute of Standards and Technology (NIST), the Medical University of South Carolina (MUSC), the SC Department of Natural Resources, and the College of Charleston. The Center for Marine Structural Biology sits adjacent to the newly completed Hollings Marine Laboratory and houses a 700 and 800 MHz nuclear magnetic resource instruments. The completed center is operational and meets it goal to provide state-of-the-art nuclear magnetic resonance capabilities to resolve the molecular structures of compounds that have direct relevance to human health, including marine-derived biotoxins that are tested against cancer cell lines through collaborative studies with researchers at the Hollings Cancer Center at MUSC. Funds from the DOE assisted, in part, with the purchase of NMR probes and ancillary equipment for the 800 MHz NMR instrument. In addition, developmental funds was used to support the visit of an Scientific Advisory Board and for the NMR Planning Team to visit currently operational high field NMR facilities to guide their choice of instrumentation and design of the building.