New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalis

Marine Drugs

Michael P. Gotsbacher²  Peter Karuso¹ 

[1] Department of Chemistry & Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia; E-Mail

关键词: alkaloid;    bromotyrosine;    Pseudoceratina;    sponge;    Tylodina;    antibiotics;    marine natural products;   

DOI  :  10.3390/md13031389

来源: mdpi

【 摘 要 】

Bioassay-guided fractionation of extracts from temperate Australian collections of the marine sponge Pseudoceratina purpurea resulted in the isolation and characterisation of two new and six known bromotyrosine-derived alkaloids with antibiotic activity. Surprisingly, a single specimen of the mollusc Tylodina corticalis, which was collected while feeding on P. purpurea, contained only a few of the compounds found in the sponge suggesting selective accumulation and chemical modification of sponge metabolites.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.