Statistical Research on the Bioactivity of New Marine Natural Products Discovered during the 28 Years from 1985 to 2012

Marine Drugs

Yiwen Hu²  Jiahui Chen¹  Guping Hu²  Jianchen Yu²  Xun Zhu¹  Yongcheng Lin²  Shengping Chen²  Jie Yuan² 

[1] Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China;Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education, Guangzhou 510080, China; E-Mails:

关键词: bioactivity;    marine natural products;    quantitative analysis;    novel compounds;   

DOI  :  10.3390/md13010202

来源: mdpi

【 摘 要 】

Every year, hundreds of new compounds are discovered from the metabolites of marine organisms. Finding new and useful compounds is one of the crucial drivers for this field of research. Here we describe the statistics of bioactive compounds discovered from marine organisms from 1985 to 2012. This work is based on our database, which contains information on more than 15,000 chemical substances including 4196 bioactive marine natural products. We performed a comprehensive statistical analysis to understand the characteristics of the novel bioactive compounds and detail temporal trends, chemical structures, species distribution, and research progress. We hope this meta-analysis will provide useful information for research into the bioactivity of marine natural products and drug development.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.