Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex

Marine Drugs

Shwu-Li Wu¹  Jui-Hsin Su²  Chiung-Yao Huang¹  Chi-Jen Tai¹  Ping-Jyun Sung²  Chih-Chung Liaw¹ 

[1] Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan;National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan;

关键词: soft coral;    eunicellin-based diterpenes;    cytotoxicity;    Klyxum simplex;   

DOI  :  10.3390/md10061203

来源: mdpi

【 摘 要 】

Four new eunicellin-based diterpenes, simplexins P–S (1–4), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3–5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.