Sarcophyolides B–E, New Cembranoids from the Soft Coral Sarcophyton elegans

Marine Drugs

Zhifang Xi³  Wei Bie³  Wei Chen³  Dong Liu³  Leen van Ofwegen²  Peter Proksch¹ 

[1] Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Duesseldorf, Germany; E-Mail:;Naturalis Biodiversity Center, National Museum of Natural History, Leiden 2300, The Netherlands; E-Mail:;State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China; E-Mails:

关键词: soft coral;    Sarcophyton elegans;    sarcophyolide;    cembranoid;    cytotoxicity;   

DOI  :  10.3390/md11093186

来源: mdpi

【 摘 要 】

Four new cembrane-type diterpenoids, sarcophyolides B–E (1–4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1–4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocrasol were found to exhibit potent inhibition against A2780 human ovarian tumor cells.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.