Terpenoids from the Soft Coral Sinularia sp. Collected in Yongxing Island

Marine Drugs

Xu-Li Tang¹  Xiang-Chao Luo²  Yan-Ting Sun²  Guo-Fei Qin²  Jing Zhang²  Ping-Lin Li²  Guo-Qiang Li²  Leen van Ofwegen³  Ping-Jyun Sung⁴ 

[1] College of Chemistry and Chemical Engineering, Ocean University of China, Songling Road 238, Qingdao 266100, China;Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Yushan Road 5, Qingdao 266003, China;Nationaal Natuurhistorisch Museum, P.O. Box 9517, 2300 BA Leiden, The Netherlands;National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan;

关键词: soft coral;    Sinularia sp.;    sesquiterpenoid;    cembranoid;    antimalarial;    cytotoxicities;    antiviral;    targets inhibitory activities;   

DOI  :  10.3390/md16040127

来源: DOAJ

【 摘 要 】

Three new sesquiterpenoids (sinuketal (1), sinulins A and B (2 and 3)) and two new cembranoids (sinulins C and D (4 and 5)), as well as eight known sesquiterpenoids (6–13) and eight known cembranoids (14–21), were isolated from the Xisha soft coral Sinularia sp. Their structures were elucidated by extensive spectroscopic analysis. Compound 1 possesses an unprecedented isopropyl-branched bicyclo [6.3.0] undecane carbon skeleton with unique endoperoxide moiety, and a plausible biosynthetic pathway of it was postulated. According to the reported biological properties of endoperoxide, the antimalarial, cytotoxic, antiviral, and target inhibitory activities of 1 were tested. Compound 1 showed mild in vitro antimalarial activity against Plasmodium falciparum 3D7, weak cytotoxic activities toward Jurkat, MDA-MB-231, and U2OS cell lines, inhibitory effects against influenza A viruses H1N1 and PR8, as well as mild target inhibitory activity against acetylcholinesterase. The other compounds were evaluated for cytotoxicities against HeLa, HCT-116, and A549 tumor cell lines and target inhibitory activities against protein tyrosine phosphatase 1B (PTP1B). Compound 20 exhibited cytotoxicities against HeLa and HCT-116, and compounds 5, 11, and 15 showed mild target inhibitory activities against PTP1B.

【 授权许可】

Unknown