Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans

Molecules

Xin Liu¹  Junsheng Zhang¹  Qiao Liu¹  Guihua Tang¹  Hongsheng Wang¹  Chengqi Fan²  Sheng Yin¹ 

[1] School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; E-Mails:;East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China; E-Mail:

关键词: Sarcophyton elegans;    cembranoids;    antimigratory activity;   

DOI  :  10.3390/molecules200713324

来源: mdpi

【 摘 要 】

Four new cembranoids, sarcophelegans A–D (1–4) and six known analogues (5–10) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were elucidated through detailed spectroscopic analysis, and the absolute configuration of 1 was confirmed by single-crystal X-ray diffraction. The antimigratory potential of compounds 1–10 were evaluated and compounds 2 and 6 were found to inhibit human breast tumor MDA-MB-231 cell migration at 10 μM.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.