Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.

Marine Drugs

Min Zhao¹  Jian Yin¹  Wei Jiang³  Minshan Ma²  Xinxiang Lei²  Zheng Xiang¹  Jianyong Dong¹  Kexin Huang¹ 

[1] School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, China; E-Mails:;Analytical and Testing Center, Wenzhou University, Wenzhou 325035, China; E-Mails:;College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225127, China; E-Mail:

关键词: soft coral;    Lobophytum;    cembranoids;    cytotoxicity;    antibacterial activity;   

DOI  :  10.3390/md11041162

来源: mdpi

【 摘 要 】

Chemical examination of a South China Sea soft coral Lobophytum sp. led to the isolation of three new α-methylene-γ-lactone-containing cembranoids, (1R*,3R*,4R*,14R*,7E,11E)-3,4-epoxycembra-7,11,15(17)-trien-16,14-olide (1), (1R*,7S*,14S*,3E,11E)-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (2), and (1R*,7S*,14S*,3E,11E)-18-acetoxy-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (3), along with eleven known analogues 4–14. The structures of the new compounds were elucidated through extensive spectroscopic analysis, including 1D and 2D NMR data. Compounds 1–3 exhibited moderate cytotoxic activity against the selected tumor cell lines. Moreover, 2 and 3 were found to be moderate inhibitors against the bacteria S. aureus and S. pneumoniae.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.