Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis

International Journal of Molecular Sciences

Chao-Ying Kuo¹  Yung-Shun Juan³  Mei-Chin Lu¹  Michael Yen-Nan Chiang⁴  Chang-Feng Dai⁵  Yang-Chang Wu² 

[1] Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944,Taiwan; E-Mails:;School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan;Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan; E-Mail:;Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mail:;Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan; E-Mail:

关键词: soft coral;    pregnane;    Scleronephthya flexilis;    cytotoxicity;    MOLT-4;   

DOI  :  10.3390/ijms150610136

来源: mdpi

【 摘 要 】

Three pregnane-type steroids, including a new metabolite, 3β-methoxy-5,20-pregnadiene (1) along with two known analogues, 3β-acetoxy-5,20-pregnadiene (2) and 5α-pregna-1,20-dien-3-one (3) were isolated from the soft coral Scleronephthya flexilis. Standard spectroscopic techniques were used to determine the structure of new steroid 1. The absolute stereochemistry of steroid 2 was confirmed by X-ray diffraction analysis. Steroid 3 exhibited potent activity against MOLT-4 tumor cells.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.