Synergistic Effect of Glycyrrhizic Acid and ZnO/Palygorskite on Improving Chitosan-Based Films and Their Potential Application in Wound Healing

Polymers

Junjie Ding¹  Hong Zhang¹  Aiping Hui¹  Aiqin Wang¹  Xinyue Liu²  Qian Zhang² 

[1] Key Laboratory of Clay Mineral Applied Research of Gansu Province, Center of Eco-Material and Green Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China;Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou 730030, China;

关键词: chitosan;    glycyrrhizic acid;    ZnO/PAL;    antibacterial;    nanocomposite films;   

DOI  :  10.3390/polym13223878

来源: DOAJ

【 摘 要 】

The synergistic effect of chitosan (CS), glycyrrhizic acid (GA) and ZnO/palygorskite (ZnO/PAL) as potential wound dressing was evaluated in the form of films by the solution casting method. The nanocomposite films were well-characterized with ATR-FTIR, XRD and SEM to explore the interactions between CS, GA and ZnO/PAL. Physical, mechanical and antibacterial properties of the nanocomposite films were systematically investigated for their reliability in end-up utilization. Importantly, it was found that the presence of PAL in the films provided enhanced mechanical properties, whereas CS, GA and ZnO supplied a broad-spectrum antibacterial activity, especially for drug-resistant bacteria such as ESBL—E. coli and MRSA. Overall, this research demonstrated that the prepared films can be a promising candidate for wound-care materials.

【 授权许可】

Unknown