Biogenic Preparation, Characterization, and Biomedical Applications of Chitosan Functionalized Iron Oxide Nanocomposite

Journal of Composites Science

Neeraj Mishra¹  Vijay Kumar Thakur²  Devaraj Bharathi³  Belay Zeleke Sibuh⁴  Piyush Kumar Gupta⁵  Soumya Pandit⁵  Sharad Agrawal⁵  Mohit Sahni⁶  Ranjithkumar Rajamani⁷ 

[1] Amity Institute of Pharmacy, Amity University, Gwalior 474005, India;Biorefining and Advanced Materials Research Centre, Scotland’s Rural College (SRUC), Kings Buildings, Edinburgh EH9 3JG, UK;Department of Biotechnology, Hindusthan College of Arts and Science, Coimbatore 6410028, India;Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201310, India;Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Greater Noida 201310, India;Department of Physics, School of Basic Sciences and Research, Sharda University, Greater Noida 201310, India;Viyen Biotech LLP, Coimbatore 6410021, India;

关键词: chitosan;    FeO;    nanocomposite;    antibacterial;    anticancer;   

DOI  :  10.3390/jcs6050120

来源: DOAJ

【 摘 要 】

Chitosan (CS) functionalization over nanomaterials has gained more attention in the biomedical field due to their biocompatibility, biodegradability, and enhanced properties. In the present study, CS functionalized iron (II) oxide nanocomposite (CS/FeO NC) was prepared using Sida acuta leaf extract by a facile and eco-friendly green chemistry route. Phyto-compounds of S. acuta leaf were used as a reductant to prepare CS/FeO NC. The existence of CS and FeO crystalline peaks in CS/FeO NC was confirmed by XRD. FE-SEM analysis revealed that the prepared CS/FeO NC were spherical with a 10–100 nm average size. FTIR analyzed the existence of CS and metal-oxygen bands in the prepared NC. The CS/FeO NC showed the potential bactericidal activity against E. coli, B. subtilis, and S. aureus pathogens. Further, CS/FeO NC also exhibited the dose-dependent anti-proliferative property against human lung cancer cells (A549). Thus, the obtained outcomes revealed that the prepared CS/FeO NC could be a promising candidate in the biomedical sector to inhibit the growth of bacterial pathogens and lung cancer cells.

【 授权许可】

Unknown