Preparation and Characterization of Vancomycin Hydrochloride-Loaded Mesoporous Silica Composite Hydrogels

Frontiers in Bioengineering and Biotechnology

Yaoxiang Xu¹  Liqiang Chen²  Dongyang Zhou⁴  Lidi Cheng⁴  Zexian Xu⁴  Ming Sun⁴  Xiuxiu Zhang⁴  Jian Sun⁴  Yanshan Liu⁴  Qihui Zhou⁵ 

[1] 3D Printing Engineering Laboratory of Qingdao, Qingdao, China;;Dental Digital Medicine &Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China;School of Stomatology of Qingdao University, Qingdao, China;The Affiliated Hospital of Qingdao University, Qingdao, China;

关键词: biomaterials;    hydrogel;    drug delivery;    biocompatibility;    antibacterial;   

DOI  :  10.3389/fbioe.2022.826971

来源: DOAJ

【 摘 要 】

This study aims to explore the feasibility of the novel temperature-sensitive hydrogel-based dual sustained-release system (Van/SBA-15/CS-GP-SA) in the repair and treatment of infectious jaw defects. Van/SBA-15 was prepared using the mesoporous silica (SBA-15) as a carrier for vancomycin hydrochloride (Van), and Van/SBA-15 was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectrometry (EDS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), Brunauer–Emmett–Teller (BET), and Barrett–Joyner–Halenda (BJH). The characterization results confirm that Van is loaded in SBA-15 successfully. Van/SBA-15/CS-GP-SA is constructed by encapsulating Van/SBA-15 in chitosan–sodium glycerophosphate–sodium alginate hydrogel (CS-GP-SA). The microstructures, sustained-release ability, biocompatibility, and antibacterial properties of Van/SBA-15/CS-GP-SA were systematically studied. Van/SBA-15/CS-GP-SA is found to have promising sustained-release ability, outstanding biocompatibility, and excellent antibacterial properties. This study provides new ideas for the management of infectious jaw defects.

【 授权许可】

Unknown