Overcoming barriers: a review on innovations in drug delivery to the middle and inner ear

Frontiers in Pharmacology

Pharmacology

Joey Lye¹  Lawrence J. Liew²  Marcus D. Atlas³  Elaine Y. M. Wong³  Derek S. Delaney⁴ 

[1] Hearing Therapeutics, Ear Science Institute Australia, Nedlands, WA, Australia;Hearing Therapeutics, Ear Science Institute Australia, Nedlands, WA, Australia;Centre for Ear Sciences, Medical School, The University of Western Australia, Nedlands, WA, Australia;Hearing Therapeutics, Ear Science Institute Australia, Nedlands, WA, Australia;Centre for Ear Sciences, Medical School, The University of Western Australia, Nedlands, WA, Australia;Faculty of Health Sciences, Curtin Medical School, Curtin University, Bentley, WA, Australia;Hearing Therapeutics, Ear Science Institute Australia, Nedlands, WA, Australia;Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia;

关键词: drug delivery;    inner ear;    middle ear;    hydrogel;    nanoparticle;    biomaterials;    microdevices;   

DOI  :  10.3389/fphar.2023.1207141

 received in 2023-04-18, accepted in 2023-10-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

Despite significant advances in the development of therapeutics for hearing loss, drug delivery to the middle and inner ear remains a challenge. As conventional oral or intravascular administration are ineffective due to poor bioavailability and impermeability of the blood-labyrinth-barrier, localized delivery is becoming a preferable approach for certain drugs. Even then, localized delivery to the ear precludes continual drug delivery due to the invasive and potentially traumatic procedures required to access the middle and inner ear. To address this, the preclinical development of controlled release therapeutics and drug delivery devices have greatly advanced, with some now showing promise clinically. This review will discuss the existing challenges in drug development for treating the most prevalent and damaging hearing disorders, in particular otitis media, perforation of the tympanic membrane, cholesteatoma and sensorineural hearing loss. We will then address novel developments in drug delivery that address these including novel controlled release therapeutics such as hydrogel and nanotechnology and finally, novel device delivery approaches such as microfluidic systems and cochlear prosthesis-mediated delivery. The aim of this review is to investigate how drugs can reach the middle and inner ear more efficiently and how recent innovations could be applied in aiding drug delivery in certain pathologic contexts.

【 授权许可】

Unknown   
Copyright © 2023 Delaney, Liew, Lye, Atlas and Wong.