Promising biocompatible hydrogels of crosslinked polyelectrolytes for biomedical applications

Current Directions in Biomedical Engineering

Illner Sabine¹  Grabow Niels¹  Brietzke Andreas¹  von der Ehe Christian²  Kragl Udo²  Matschegewski Claudia³ 

[1] Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Straße 4, D-18119 Rostock, Germany;Institute for Chemistry, University of Rostock, Albert-Einstein-Straße 3a, D-18059 Rostock, Germany;Institute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Strasse 4, D-18119 Rostock, Germany;

关键词: biocompatibility;    hydrogel;    ionic liquid;    implant;    drug depot;   

DOI  :  10.1515/cdbme-2017-0147

来源: DOAJ

【 摘 要 】

For the development of intelligent implant systems hydrogels (HG) from crosslinked ionic liquids feature a high potential to be utilised as a drug depot. Biocompatibility of the HGs is one key prerequisite for biomedical applications. HGs were polymerised from a variety of different ionic monomers based on methacrylate, methacrylamide, styrene or vinyl imidazolium derivatives in aqueous solution. N,N'-methylenebisacrylamide was used as crosslinker. CellQuanti-Blue™ Cell Viability Assay Kit was implemented to proof viability of L929 mouse fibroblasts. The predominant part of the HG eluates generated only a marginal reduction of less than 15% cell viability at 100% eluate concentration. This underlines the excellent suitability of these HGs for biomedical applications and revealed some promising candidates for the development of drug depots for implants.

【 授权许可】

Unknown