Hydrogel Tissue Expanders for Stomatology. Part II. Poly(styrene-maleic anhydride) Hydrogels

Polymers

Roman Smucler¹  Petr Lesny²  Jakub Sirc³  Martin Hruby³  Radka Hobzova³  Jiri Hodan³  Jiri Michalek³  Eva Chylikova Krumbholcova³  Miroslava Duskova-Smrckova³  Jakub Hrib³ 

[1] 1st Faculty of Medicine, Charles University in Prague, Katerinska 32, 121 08 Prague 2, Czech Republic;Institute of Hematology and Blood Transfusion, U nemocnice 2094/1, 128 20 Prague 2, Czech Republic;Institute of Macromolecular Chemistry AS CR, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic;

关键词: hydrogel;    self-inflating tissue expander;    styrene-maleic anhydride copolymers;    swelling;    volume expansion;    mechanical properties;    biocompatibility;    in vivo;   

DOI  :  10.3390/polym11071087

来源: DOAJ

【 摘 要 】

Self-inflating soft tissue expanders represent a valuable modality in reconstructive surgery. For this purpose, particularly synthetic hydrogels that increase their volume by swelling in aqueous environment are used. The current challenge in the field is to deliver a material with a suitable protracted swelling response, ideally with an induction period (for sutured wound healing) followed by a linear increase in volume lasting several days for required tissue reconstruction. Here, we report on synthesis, swelling, thermal, mechanical and biological properties of novel hydrogel tissue expanders based on poly(styrene-alt-maleic anhydride) copolymers covalently crosslinked with p-divinylbenzene. The hydrogels exerted hydrolysis-driven swelling response with induction period over the first two days with minimal volume change and gradual volume growth within 30 days in buffered saline solution. Their final swollen volume reached more than 14 times the dry volume with little dependence on the crosslinker content. The mechanical coherence of samples during swelling and in their fully swollen state was excellent, the compression modulus of elasticity being between 750 and 850 kPa. In vitro cell culture experiments and in vivo evaluation in mice models showed excellent biocompatibility and suitable swelling responses meeting thus the application requirements as soft tissue expanders.

【 授权许可】

Unknown