Characterization and Properties of Hydrogels Made from Neutral Soluble Chitosans

Polymers

Henry M. Franzén¹  Kurt Ingar Draget²  Joakim Langeb์k¹  Julie Nilsen-Nygaard² 

[1] Viscogel AB, Gunnar Asplunds Allé 32D, Solna SE-171 63, Sweden; E-Mail:;Department of Biotechnology, Norwegian University of Science and Technology (NTNU), Trondheim N-7491, Norway; E-Mails:

关键词: chitosan;    Viscosan;    hydrogel;    cross-linked;    ViscoGel;    visco-elastic;    drug delivery;    stability;    swelling;   

DOI  :  10.3390/polym7030373

来源: mdpi

【 摘 要 】

The current paper focuses on the preparation and some characteristics of viscoelastic hydrogels, ViscoGels™, made from chitosans having a random acylation pattern. Three different chitosan batches with a high fraction of acetylation were selected based on their M_w, and the impact of degree of cross-linking on these chitosan samples has been studied with respect to the properties of the final hydrogels. Rheological long term (12 month) stability and gelling kinetics data are presented together with results from swelling studies at different pH. Finally, an example illustrating these gels potential as drug delivery vehicles is presented and discussed.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.