Enhanced bone regenerative properties of calcium phosphate ceramic granules in rabbit posterolateral spinal fusion through a reduction of grain size

Bioactive Materials

Limin Liu¹  Xi Yang²  Linnan Wang²  Xingdong Zhang²  Quan Zhou²  Yueming Song²  Cong Feng³  Kai Zhang³  Yumei Xiao³  Xiangdong Zhu³  Xiangfeng Li³  Yonghao Wu³ 

[1] Corresponding author.;Department of Orthopaedic Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China;National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China;

关键词: Calcium phosphate ceramics;    Nanotopography;    Osteogenic differentiation;    Osteoinductivity;    Posterolateral spinal fusion;   

DOI  :  

来源: DOAJ

【 摘 要 】

Osteoinductivity is a crucial factor to determine the success and efficiency of posterolateral spinal fusion (PLF) by employing calcium phosphate (Ca-P) bioceramics. In this study, three kinds of Ca-P ceramics with microscale to nanoscale gain size (BCP-control, BCP-micro and BCP-nano) were prepared and their physicochemical properties were characterized. BCP-nano had the spherical shape and nanoscale gain size, BCP-micro had the spherical shape and microscale gain size, and BCP-control (BAM®) had the irregular shape and microscale gain size. The obtained BCP-nano with specific nanotopography could well regulate in vitro protein adsorption and osteogenic differentiation of MC3T3 cells. In vivo rabbit PLF procedures further confirmed that nanotopography of BCP-nano might be responsible for the stronger bone regenerative ability comparing with BCP-micro and BCP-control. Collectedly, due to nanocrystal similarity with natural bone apatite, BCP-nano has excellent efficacy in guiding bone regeneration of PLF, and holds great potentials to become an alternative to standard bone grafts for future clinical applications.

【 授权许可】

Unknown