Divalent Metal Ions Induced Osteogenic Differentiation of MC3T3E1

5th Annual International Conference on Material Science and Engineering

Wang, Guoshou^1 ; Su, Wenta^2 ; Chen, Pohung^2 ; Huang, Teyang^1

Department of Orthopedic Surgery, Mackay Memorial Hospital, Taipei, Taiwan^1

Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 1 Sec. 3, Chung-Hsiao E. Rd., Taipei

10608, Taiwan^2

关键词: ALkaline phosphatase;    Biochemical signal;    Biomaterial scaffolds;    Bone tissue engineering;    Divalent metal ion;    Osteoblastic differentiation;    Osteoconductive properties;    Osteogenic differentiation;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/275/1/012004/pdf
DOI  :  10.1088/1757-899X/275/1/012004

来源: IOP

【 摘 要 】

Biomaterial scaffolds blended with biochemical signal molecules with adequate osteoinductive and osteoconductive properties have attracted significant interest in bone tissue engineering regeneration. The divalent metal ions can gradually release from the scaffold into the culture medium and then induced osteoblastic differentiation of MC3T3E1. These MC3T3E1 cells expressed high activity of alkaline phosphatase, bone-related gene expression of collagen type I, Runx2, osteopontin, osteocalcin, and significantly enhanced deposited minerals on scaffold after 21 days of culture. This experiment provided a useful inducer for osteogenic differentiation in bone repair.