Sudoku of porous, injectable calcium phosphate cements – Path to osteoinductivity

Bioactive Materials

Janis Locs¹  Agneta Vezenkova² 

[1] Corresponding author.;Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of Genera Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Pulka Street 3, LV-1007, Riga, Latvia;

关键词: Calcium phosphate cements;    Bone cements;    Bone regeneration;    Osteoinductivity;   

DOI  :  

来源: DOAJ

【 摘 要 】

With the increase of global population, people's life expectancy is growing as well. Humans tend to live more active lifestyles and, therefore, trauma generated large defects become more common. Instances of tumour resection or pathological conditions and complex orthopaedic issues occur more frequently increasing necessity for bone substitutes. Composition of calcium phosphate cements (CPCs) is comparable to the chemical structure of bone minerals. Their ability to self-set and resorb in vivo secures a variety of potential applications in bone regeneration. Despite the years-long research and several products already reaching the market, finding the right properties for calcium phosphate cement to be osteoinductive and both injectable and suitable for clinical use is still a sudoku. This article is focused on injectable, porous CPCs, reviewing the latest developments on the path toward finding osteoinductive material, which is suitable for injection.

【 授权许可】

Unknown