Study of Nano-Hydroxyapatite:Poly Lactide Acid (n-HA:PLA) Composites and Their Biocompatibility, Bioactivity, and Biodegradability Characteristics

International Conference on Condensed Matters and Advanced Materials 2018

Yudyanto^1 ; Hardianti, D.^1 ; Hartatiek^1 ; Hidayat, N.^1 ; Kurniawan, R.^1

Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang 5, Malang, East Java

65145, Indonesia^1

关键词: Biocompatibility tests;    Bone regeneration;    Crystal structure and morphology;    Nano-hydroxyapatite;    Natural materials;    Polylactide acids;    Sonication method;    X ray diffractometers;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/515/1/012034/pdf
DOI  :  10.1088/1757-899X/515/1/012034

来源: IOP

【 摘 要 】

A synthesis of nano-hydroxyapatite:polylactide acid (n-HA:PLA) composites based on natural materials has been performed. The synthesis was performed using sonication method, with a variation of n-HA:PLA ratio of 90:10, 80:20, 70:30, 60:40, 50:50 in %wt. The crystal structure and morphology of the sample were characterized by using X-ray diffractometer (XRD) and scanning electron microscopy (SEM). The bioactivity and biodegradable tests were performed in vitro using Krebs solution. Meanwhile, the biocompatibility test was performed by a separate bath organ method. The results show that for all compositions of n-HA:PLA exhibit a biocompatible characteristic. The sample with a ratio of 90:10 %wt shows higher bioactivity and biodegradability properties than other compositions. Our result would give a good understanding of the synthesis and biocompatibility, bioactivity, and biodegradability of n-HA:PLA composite, which is crucial for bone regeneration.