Anti-angiogenesis and apoptogenic potential of the brown marine alga, Chnoospora minima

Future Journal of Pharmaceutical Sciences

Varalakshmi K. Nadumane¹  Shabana Parveen¹ 

[1] Department of Biotechnology, School of Sciences, Jain (Deemed-to-be- University);

关键词: Angiogenesis;    Apoptosis;    Bax;    Caspase;    Chnoospora minima;    p53 expression;   

DOI  :  10.1186/s43094-020-00039-9

来源: DOAJ

【 摘 要 】

Abstract Background Algae being one of the dominant organisms in nature can provide best opportunity for the discovery of new anti-cancer drugs. The aim of the present study was to investigate the anti-cancer and anti-angiogenic potential of the brown marine alga Chnoospora minima. Result The methanol extract of C. minima and its bioactive fraction (CF4) have highly significant cytotoxic effects to HepG2, HeLa and MCF-7 cancer cell lines. The fraction’s ability to induce apoptosis in the cancer cells was evidenced by increased caspase activity (caspase-3, 7 and 10), DNA fragmentation pattern and upregulated expressions of Bax and p53 genes. The bioactive fraction was not toxic to human peripheral lymphocytes. HPLC, ESI-MS and GC-MS analysis of CF4 fraction indicated the presence of the compound hexadecanoic acid which might be responsible for the observed anti-cancer activity of C. minima. The methanol extract of C. minima exhibited anti-angiogenic effects on chick embryos. Conclusion It can be concluded that fraction, CF4, from C. minima is a promising source of an anti-cancer lead molecule.

【 授权许可】

Unknown