Application of magnetic nanoparticles in nucleic acid detection

Journal of Nanobiotechnology

Hongmei Liu¹  Gaojian Yang¹  Song Li¹  Hui Chen¹  Ziyu He¹  Yan Deng¹  Congli Tang¹  Hao Huang¹  Yuyue Xu¹  Ziqi Xiao¹  Hongna Liu¹  Zhu Chen¹  Nongyue He² 

[1] Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology;State Key Laboratory of Bioelectronics, Southeast University;

关键词: Magnetic nanoparticles;    Nucleic acid detection;    High-throughput sequencing;    Clinical diagnosis;    Magnetic separation;   

DOI  :  10.1186/s12951-020-00613-6

来源: DOAJ

【 摘 要 】

Abstract Nucleic acid is the main material for storing, copying, and transmitting genetic information. Gene sequencing is of great significance in DNA damage research, gene therapy, mutation analysis, bacterial infection, drug development, and clinical diagnosis. Gene detection has a wide range of applications, such as environmental, biomedical, pharmaceutical, agriculture and forensic medicine to name a few. Compared with Sanger sequencing, high-throughput sequencing technology has the advantages of larger output, high resolution, and low cost which greatly promotes the application of sequencing technology in life science research. Magnetic nanoparticles, as an important part of nanomaterials, have been widely used in various applications because of their good dispersion, high surface area, low cost, easy separation in buffer systems and signal detection. Based on the above, the application of magnetic nanoparticles in nucleic acid detection was reviewed.

【 授权许可】

Unknown