Mechanism and Target Spot of Burn and Burn Treatment Based on Network Pharmacology

2019 5th International Conference on Energy Materials and Environment Engineering

能源学;生态环境科学

Chu, Keke^1 ; Miao, Mingsan^1

Henan University of Chinese Medicine, 450046, China^1

关键词: Active substance;    Clinical diagnosis;    Common disease;    Mechanism of action;    Network pharmacologies;    Physiological functions;    Potential targets;    Research strategy;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/295/3/032011/pdf
DOI  :  10.1088/1755-1315/295/3/032011

学科分类：环境科学（综合）

来源: IOP

【 摘 要 】

Burn and scald is a local or systemic acute injury disease caused by various reasons acting on human body and a common disease in daily life. Network pharmacology is a new research strategy to reveal the mechanism of drug therapy and potential targets of diseases from the system level based on the network point of view.The theory of neuroendocrine-immune network ( NEI ) holds that there are cross reactions among nerve medium, endocrine hormone and immune active substances in the immune system to form channels for mutual regulation among the three systems, thus maintaining the body's steady state and normal physiological functions on the overall level. This article takes neuroendocrine immunity as the main line to analyze and summarize the therapeutic mechanism and mechanism of burns and scalds from different aspects. With the help of network pharmacology, the potential targets of burns and scalds are systematically screened and discussed as a whole, and the target changes involved in the mechanism of action are combined with the targets mined by network pharmacology, so as to provide theoretical and clinical basis for clinical diagnosis, treatment and new prescriptions.