Gracilosulfates A–G, Monosulfated Polyoxygenated Steroids from the Marine Sponge Haliclona gracilis

Marine Drugs

卷:18

Gunhild von Amsberg¹  PavelS. Dmitrenok²  VladimirA. Denisenko²  LarisaK. Shubina²  TatyanaN. Makarieva²  SergeyA. Dyshlovoy²  ValentinA. Stonik²  RomanS. Popov²  BorisB. Grebnev² 

[1] Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany;

[2] G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia;

关键词: polyoxygenated steroids;    sponge;    Haliclona gracilis;    anticancer activity;   

DOI  :  10.3390/md18090454

来源: DOAJ

【 摘 要 】

Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A–G (1–7), possessing 3β-O-sulfonato, 5β,6β epoxy (or 5(6)-dehydro), and 4β,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Haliclona gracilis. Their structures were determined by NMR and MS methods. The compounds 1, 2, 4, 6, and 7 inhibited the expression of prostate-specific antigen (PSA) in 22Rv1 tumor cells.

【 授权许可】

Unknown