Structure Elucidation and Cytotoxic Evaluation of New Polyacetylenes from a Marine Sponge Petrosia sp.

International Journal of Molecular Sciences

Yung-Shun Juan⁵  Chien-Chih Lee³  Chia-Wei Tsao⁴  Mei-Chin Lu⁴  Mohamed El-Shazly¹  Huei-Chuan Shih⁶  Yu-Cheng Chen⁴  Yang-Chang Wu² 

[1] Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo 11566, Egypt; E-Mail:;School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan;Epigenome Research Center, Department of Laboratory Medicine, China Medical University Hospital, Taichung 404, Taiwan; E-Mail:;Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan; E-Mails:;Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan; E-Mail:;Department of Nursing, Meiho University, Pingtung 912, Taiwan; E-Mail:

关键词: sponge;    Petrosia;    polyacetylene;   

DOI  :  10.3390/ijms150916511

来源: mdpi

【 摘 要 】

The sponge Petrosia sp. yielded five polyacetylenic compounds (1–5), including two new polyacetylenes, petrosianynes A (1) and B (2). The structures of these compounds were elucidated by detailed spectroscopic analysis and by comparison with the physical and spectral data of related known analogues. Compounds 1–5 exhibited significant cytotoxic activity against a limited panel of cancer cell lines.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.