Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity

Marine Drugs

Guang-Xiong Zhou¹ 

[1] id="af1-marinedrugs-01-00046">Department of Chemistry, University of California, Davis, California 95616, USA. Tel. [phone], Fax [phone]

关键词: Porifera;    ene-yne;    HCT-116;    cytotoxic activity;    polyacetylene;    pellynol;   

DOI  :  10.3390/md101046

来源: mdpi

【 摘 要 】

Two new long-chain C₃₃ polyacetylenic compounds, halicynones A and B were isolated from the marine sponge Haliclona sp. along with known analogs. The known compound pellynol A possessing a 1-yn-3-ol terminus, exhibited strong antitumor activity against the human colon tumor cell line HCT-116 (IC₅₀ 0.026 μg/mL), however, the corresponding 1-yn-3-one, halicynone A, was inactive, which suggests an important role for the terminal 1-yn-3-ol functional group in mediating cytotoxic activity.

【 授权许可】

Unknown   
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