Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity

Marine Drugs

Maria Izabel G. Moritz²  Lucas Lourenço Marostica²  Éverson M. Bianco²  Maria Tereza R. Almeida²  João L. Carraro³  Gabriela M. Cabrera¹  Jorge A. Palermo¹  Cláudia M. O. Simཞs²  Eloir P. Schenkel² 

[1] UMYMFOR—Department of Organic Chemistry, FCEN, University of Buenos Aires, Buenos Aires C1428EGA, Argentina; E-Mails:;Post-Graduation Program in Pharmacy, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil; E-Mails:;Invertebrates Department, National Museum, Federal University of Rio de Janeiro, Rio de Janeiro 20940-040, RJ, Brazil; E-Mail:

关键词: Leptogorgia punicea;    octocoral;    polyoxygenated steroids;    cytotoxic effects;    A549 cells;    lung cancer cells;   

DOI  :  10.3390/md12125864

来源: mdpi

【 摘 要 】

Five new polyoxygenated marine steroids—punicinols A–E (1–5)—were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, ¹H, ¹³C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B were the most active, with IC₅₀ values of 9.7 μM and 9.6 μM, respectively. The synergistic effects of these compounds with paclitaxel, as well as their effects on cell cycle distribution and their performance in the clonogenic assay, were also evaluated. Both compounds demonstrated significant synergistic effects with paclitaxel.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.