期刊论文详细信息
Micro & nano letters
Effect of incorporation of highly-ordered a-Ge:H nanoparticles on the performance of perovskite solar cells
article
Zhenglong Li1  Jian Ni1  Shuaiyuan Zhang1  Chang Li1  Yangyang Du1  Yaofang Zhang2  Hongkun Cai1  Juan Li1  Jianjun Zhang1 
[1] The Tianjin Key Laboratory for Opto-Electronic Thin Film Devices and Technology, College of Electronic Information and Optical Engineering, Nankai University;College of Science, Tianjin Polytechnic University
关键词: hydrogen;    germanium;    organic compounds;    elemental semiconductors;    amorphous semiconductors;    semiconductor thin films;    nanoparticles;    solar cells;    light absorption;    narrow band gap semiconductors;    nanofabrication;    plasma CVD;    semiconductor growth;    bonds (chemical);    Raman spectra;    transmission electron microscopy;    Fourier transform infrared spectra;    perovskite solar cells;    light absorption;    narrow band gap highly-ordered free-standing hydrogenated amorphous germanium nanoparticles;    radiofrequency plasma enhanced chemical vapour deposition;    hydrogen dilution ratio;    microstructure;    bonding configuration;    Raman spectroscopy;    transmission electron microscopy;    Fourier transform infrared spectroscopy;    ultrasonic spray-coating;    visible range;    power conversion efficiency;    GeH;   
DOI  :  10.1049/mnl.2017.0876
学科分类:计算机科学(综合)
来源: Wiley
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【 摘 要 】

Abstract             Itraconazole is a triazole antifungal given orally for the treatment of oropharyngeal and vulvovaginal candidiasis, for systemic infections including aspergillosis, candidiasis,  and for the prophylaxis of fungal infections in immunocompromised patients.            The study aimed to formulate a practical water-insoluble Itraconazole, with insufficient bioavailability as nanosuspension to increase aqueous solubility and improve its dissolution and oral bioavailability.           Itraconazole nanosuspension was produced by a solvent-antisolvent nanoprecipitation method in the presence of different stabilisers (Poloxamer-188, HPMCE5) at different ratios with the drug alone or combination with surfactant(tween 80, SLS).          The results exhibit that the particle sizes of all prepared itraconazole formulations were in the nano size.  The best formula (F6) has a particle size.  ( 42  ) nm and Zeta potential of (- 21.86 ) mV.  In vitro cumulative release from the nanosuspension was (88 %) at (30) min when compared to the pure drug (13%) and lyophilized nanoparticles (98.2%) at (30)min. Effect of different parameters was investigated.           Fourier transforms infrared spectroscopy(FTIR), Differential scanning calorimetry (DSC) and X-ray diffraction (XRD), Scanning electron microscope( SEM) was done for the optimized  nanoparticles prepared by lyophilization technique         Thus, Nanosuspension appears to be an encouraging approach to formulate Itraconazole nanosuspension with high solubility and dissolution rate.

【 授权许可】

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