Cembranoids of Soft Corals: Recent Updates and Their Biological Activities

Natural Products and Bioprospecting

Fauzia Izzati¹  Mega Ferdina Warsito¹  Asep Bayu¹  Siti Irma Rahmawati¹  Marsya Yonna Nurrachma¹  Linda Sukmarini¹  Deamon Sakaraga¹  Akhirta Atikana¹  Ahmad Yogi Nugraha¹  Anggia Prasetyoputri¹  Masteria Yunovilsa Putra¹ 

[1] Research Center for Biotechnology, Indonesian Institute of Sciences (LIPI), Jalan Raya Jakarta-Bogor KM. 46, Cibinong, Bogor, West Java, Indonesia;

关键词: Cembranoids;    Diterpene;    Soft corals;    Sarcophyton;    Sinularia;    Lobophytum;    Anti-bacterial;    Anti-cancer;    Anti-inflammatory;   

DOI  :  10.1007/s13659-021-00303-2

来源: Springer

【 摘 要 】

Soft corals are well-known as excellent sources of marine-derived natural products. Among them, members of the genera Sarcophyton, Sinularia, and Lobophytum are especially attractive targets for marine natural product research. In this review, we reported the marine-derived natural products called cembranoids isolated from soft corals, including the genera Sarcophyton, Sinularia, and Lobophytum. Here, we reviewed 72 reports published between 2016 and 2020, comprising 360 compounds, of which 260 are new compounds and 100 are previously known compounds with newly recognized activities. The novelty of the organic molecules and their relevant biological activities, delivered by the year of publication, are presented. Among the genera presented in this report, Sarcophyton spp. produce the most cembranoid diterpenes; thus, they are considered as the most important soft corals for marine natural product research. Cembranoids display diverse biological activities, including anti-cancer, anti-bacterial, and anti-inflammatory. As cembranoids have been credited with a broad range of biological activities, they present a huge potential for the development of various drugs with potential health and ecological benefits.Graphic Abstract

【 授权许可】

CC BY