New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals

Marine Drugs

Isabelle Bonnard²  Sabina B. Jhaumeer-Laulloo¹  Nataly Bontemps²  Bernard Banaigs² 

[1] Department of Chemistry, University of Mauritius, Réduit, Mauritius; E-Mail:;Laboratoire de Chimie des Biomolécules et de l’Environnement, Centre de Phytopharmacie, Université de Perpignan, 52 avenue Paul Alduy, 66860 Perpignan Cedex, France

关键词: lobane;    cembrane;    acetylcholinesterase inhibitors;    Sarcophyton;    Lobophytum;   

DOI  :  10.3390/md8020359

来源: mdpi

【 摘 要 】

Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fractionations provided a known antitumor promoter cembrane diterpenoid, (+)-sarcophytol-A (1), along with a new lobane diterpenoid, carbomethoxyfuscol (2), from Sarcophyton sp., and a new cembranoid, crassumolide E (3), from Lobophytum sp. The structures of compounds 1–3 were determined by spectroscopic analysis and by comparison of the spectral data with previously reported values. The cembranoid 3 was found to exhibit a moderate inhibitory effect on acetylcholinesterase.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland