期刊论文详细信息
Molecules
New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris
Ting-Hsi Hsiao5  Ching-Hsiao Cheng3  Tung-Ying Wu2  Mei-Chin Lu5  Wu-Fu Chen3  Zhi-Hong Wen4  Chang-Feng Dai6  Yang-Chang Wu2  Ping-Jyun Sung5  Derek J. McPhee1 
[1] Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan;;Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan; E-Mail:;Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan; E-Mails:;Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan; E-Mail:;Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan; E-Mails:;Institute of Oceanography, National Taiwan University, Taipei 10617, Taiwan; E-Mail:
关键词: Nephthea columnaris;    octocoral;    cembrane;    nephalsterol;    cytotoxicity;   
DOI  :  10.3390/molecules200713205
来源: mdpi
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【 摘 要 】

Two new 15-hydroxycembranoid diterpenes, 2β-hydroxy-7β,8α-epoxynephthenol (1) and 2β-hydroxy-11α,12β-epoxynephthenol (2), were isolated from extracts of the octocoral Nephthea columnaris along with a new natural cembrane, epoxynephthenol (3) and a known sterol, nephalsterol A (4). The structures of cembranes 13 were elucidated by spectroscopic methods and comparison of the spectroscopic data with those of related analogues. The cytotoxicity of metabolites 14 against a panel of tumor cells is also described.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

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