New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris

Marine Drugs

Chun-Sung Sung¹  Yi-Chen Wang²  Zhi-Hong Wen²  Ping-Jyun Sung³  Ting-Hsi Hsiao³  Mei-Chin Lu³  Yang-Chang Wu⁴  Yu-Hsuan Lan⁴ 

[1] Department of Anesthesiology, Taipei Veterans General Hospital, Taipei 112, Taiwan;Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center,National Sun Yat-sen University, Kaohsiung 804, Taiwan;Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan;School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan;

关键词: Nephthea columnaris;    cembrane;    octocoral;    antiinflammatory;    iNOS;    COX-2;    cytotoxicity;   

DOI  :  10.3390/md13063443

来源: DOAJ

【 摘 要 】

Two new cembranes, columnariols A (1) and B (2), were isolated from the cultured soft coral Nephthea columnaris. The structures of cembranes 1 and 2 were elucidated by spectroscopic methods. In the anti-inflammatory effects test, cembranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Compound 1 exhibited moderate cytotoxicity toward LNCaP cells with an IC50 value of 9.80 μg/mL.

【 授权许可】

Unknown